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Aridhia DRE Enables the PLUTO Multi-Site Kidney Transplant Trial at Great Ormond Street Hospital
Within the DRIVE unit at Great Ormond Street Hospital, data scientists support teams to leverage clinical and operational data using their secure, trusted Digital Research Environment (DRE). The world-leading GOSH DRE, supplied by Aridhia, was launched in 2018 and to date has been involved in supporting over 350 complex data projects at GOSH.
A remarkable example of a national research project that the DRE has supported was the PLUTO study. Funded by the National Institute for Health and Care Research (NIHR), the Plasma-Lyte Usage and assessment of kidney Transplant Outcomes in children (PLUTO) was a large national randomised control trial study across 10 paediatric centres and was led by GOSH Consultant Paediatric Nephrologist, Dr Wesley Hayes.
The aim of the study was to compare the effects of the standard fluid given to patients after a kidney transplant with an alternative fluid. This involved analysing a huge volume of data from thousands of blood test data points, which without the DRE would have had to be manually collated and transferred.
The DRE platform made this technically possible and enabled collaboration, by allowing thousands of data points from across the 10 sites to be inputted into the secure platform. This allowed the study to move quickly and reduced the risk of human error in transferring the data, while giving the data science team at GOSH a centralised analytical platform to collate and clean that data within.
“The DRE and data team at GOSH DRIVE, were invaluable in the successful delivery of this clinical trial. They enabled the collation and analysis of hundreds of blood test parameters from 144 children around the UK which helped determine the safest fluid for children receiving kidney transplants.”
You can find the results of the PLUTO trial itself here.